GCN1L1
Gene Information
- Official Symbol: GCN1
- Official Name: GCN1 activator of EIF2AK4
- Aliases and Previous Symbols: N/A
- Entrez ID: 10985
- UniProt: Q92616
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF3554 |
GO Terms
| protein kinase regulator activity |
| cellular response to leucine starvation |
| translation factor activity, RNA binding |
| positive regulation of transcription from RNA polymerase II promoter in response to stress |
| polysome |
| cellular response to amino acid starvation |
| ribosome |
| response to amino acid starvation |
| ribosome binding |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| cellular response to starvation |
| response to starvation |
| cellular response to nutrient levels |
| cellular response to extracellular stimulus |
| cadherin binding |
| cellular response to external stimulus |
| regulation of translation |
| translation |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| protein kinase binding |
| response to nutrient levels |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| cellular amide metabolic process |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of transcription by RNA polymerase II |
| RNA binding |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 100/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 5/28 |
| blood | 3/28 |
| bone | 2/26 |
| breast | 5/33 |
| central nervous system | 6/56 |
| cervix | 3/4 |
| colorectal | 6/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 6/20 |
| lung | 3/75 |
| lymphocyte | 2/16 |
| ovary | 1/26 |
| pancreas | 3/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 2/9 |
| thyroid | 0/2 |
| upper aerodigestive | 6/22 |
| urinary tract | 4/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 2418
- Expression level (log2 read counts): 8.73
Expression Distribution
GCN1L1 Expression in NALM6 Cells: 8.73
