ISY1
Gene Information
- Official Symbol: ISY1
- Official Name: ISY1 splicing factor homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 57461
- UniProt: Q9ULR0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in pre-mRNA splicing. {ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| Isy1 |
GO Terms
| post-spliceosomal complex |
| first spliceosomal transesterification activity |
| generation of catalytic spliceosome for second transesterification step |
| spliceosomal conformational changes to generate catalytic conformation |
| mRNA 3-splice site recognition |
| post-mRNA release spliceosomal complex |
| U2-type catalytic step 1 spliceosome |
| Prp19 complex |
| mRNA splice site selection |
| spliceosomal complex assembly |
| transcription-coupled nucleotide-excision repair |
| catalytic step 2 spliceosome |
| nucleotide-excision repair |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| RNA splicing, via transesterification reactions |
| RNA splicing |
| ribonucleoprotein complex biogenesis |
| mRNA processing |
| DNA repair |
| mRNA metabolic process |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| cellular protein-containing complex assembly |
| RNA processing |
| RNA binding |
| protein-containing complex assembly |
| RNA metabolic process |
| cellular response to stress |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 703/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 54/56 |
| cervix | 3/4 |
| colorectal | 15/17 |
| esophagus | 10/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 18/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 20/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 1/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 26/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1656
- Expression level (log2 read counts): 5.46
Expression Distribution
ISY1 Expression in NALM6 Cells: 5.46
