MYLK3
Gene Information
- Official Symbol: MYLK3
- Official Name: myosin light chain kinase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 91807
- UniProt: Q32MK0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
GO Terms
| sarcomerogenesis |
| positive regulation of sarcomere organization |
| myosin light chain kinase activity |
| regulation of vascular permeability involved in acute inflammatory response |
| regulation of sarcomere organization |
| calmodulin-dependent protein kinase activity |
| cardiac myofibril assembly |
| regulation of vascular permeability |
| sarcomere organization |
| positive regulation of striated muscle cell differentiation |
| cardiac muscle cell development |
| cardiac cell development |
| myofibril assembly |
| acute inflammatory response |
| positive regulation of organelle assembly |
| positive regulation of muscle cell differentiation |
| cardiac muscle cell differentiation |
| regulation of actomyosin structure organization |
| regulation of striated muscle cell differentiation |
| cellular component assembly involved in morphogenesis |
| actomyosin structure organization |
| cardiocyte differentiation |
| striated muscle cell development |
| muscle cell development |
| regulation of muscle cell differentiation |
| cardiac muscle tissue development |
| vascular process in circulatory system |
| cellular response to interleukin-1 |
| positive regulation of supramolecular fiber organization |
| response to interleukin-1 |
| striated muscle cell differentiation |
| actin cytoskeleton |
| regulation of organelle assembly |
| positive regulation of cytoskeleton organization |
| muscle cell differentiation |
| striated muscle tissue development |
| muscle tissue development |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of actin filament-based process |
| blood circulation |
| circulatory system process |
| supramolecular fiber organization |
| muscle structure development |
| actin cytoskeleton organization |
| inflammatory response |
| positive regulation of cellular component biogenesis |
| heart development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| actin filament-based process |
| positive regulation of organelle organization |
| organelle assembly |
| cellular component morphogenesis |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| cellular response to cytokine stimulus |
| regulation of anatomical structure morphogenesis |
| response to cytokine |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| defense response |
| positive regulation of developmental process |
| ATP binding |
| cell development |
| tissue development |
| regulation of cell differentiation |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NUP54 | 0.511 |
| IGFN1 | 0.51 |
| SF3A3 | 0.475 |
| PSMA6 | 0.473 |
| COPG1 | 0.471 |
| EXD1 | 0.468 |
| VASN | 0.464 |
| KCTD17 | 0.459 |
| ARCN1 | 0.458 |
| INTS5 | 0.457 |
| ORC6 | 0.451 |
| NUP133 | 0.448 |
| PSMA7 | 0.448 |
| CHD4 | 0.446 |
| AAMP | 0.443 |
| TCEB3C | 0.441 |
| TBC1D3F | 0.439 |
| TBC1D3H | 0.439 |
| TCEB3CL | 0.435 |
| CCNA2 | 0.431 |
| RRM1 | 0.431 |
| DNTTIP2 | 0.429 |
| CLN6 | 0.427 |
| RBM39 | 0.426 |
| KIF3C | 0.426 |
| COPB1 | 0.424 |
| ORC1 | 0.423 |
| TCEB3CL2 | 0.42 |
| AKIRIN2 | 0.419 |
| GOLGA6A | 0.417 |
| SAP30BP | 0.416 |
| POLE | 0.416 |
| ATP6V1C1 | 0.416 |
| ANKLE1 | 0.415 |
| RRN3 | 0.415 |
| PAN3 | 0.414 |
| GID4 | 0.407 |
| SLC6A17 | 0.406 |
| TBC1D3 | 0.405 |
| ISCU | 0.405 |
| DTL | 0.405 |
| HIST2H2BF | 0.404 |
| TBC1D3G | 0.404 |
| PSMB2 | 0.404 |
| MMS22L | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2176
- Expression level (log2 read counts): 4.51
Expression Distribution
MYLK3 Expression in NALM6 Cells: 4.51
