VDAC1

Gene Information

Official Symbol: VDAC1
Official Name: voltage dependent anion channel 1
Aliases and Previous Symbols: N/A
Entrez ID: 7416
UniProt: P21796
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010].
UniProt Summary: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:8420959}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.58
GSK-J4 1μM R07 exp362	-2.11
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.1
Etoposide 1μM R00 exp19	-1.78
CFI-400945 25μM R08 exp469	1.71
Dorsomorphin 5μM R07 exp357	1.72
Atovaquone 15μM R08 exp451	1.74
CAY10603 0.55μM R08 exp467	1.79
Q15 2.7μM R02 exp79	1.79
UM0125461 0.74μM R02 exp84	1.82
Nutlin-3A 1.6μM R06 exp294	1.83
Arsenate 40μM R06 exp264	1.85
Ethanol 0.01 R05 exp234	1.86
Thapsigargin 0.005μM R07 exp407	1.88
JQ1 0.8μM R08 exp435	1.89
Bafilomycin-A1 0.009μM R08 exp454	1.99
Tubastatin-A 2.5μM R07 exp417	2.1
LY2090314 0.003μM R08 exp500 no dilution day6	2.28
LY2090314 0.003μM R08 exp499	2.54
HMS-I2 10μM R06 exp288	2.59

Gene	Correlation
PGP	0.429
HK2	0.426
PFKP	0.422

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7950
Expression level (log2 read counts): 9.04

Expression Distribution