Table of Contents

CVT-10216 0.1μM R06 exp278

Mechanism of Action

Inhibits mitochondrial aldehyde dehydrogenase (ALDH2), main enzyme for oxidative alcohol metabolism

Technical Notes

Compound References

  • PubChem Name: 3-(((3-(4-((Methylsulfonyl)amino)phenyl)-4-oxo-4H-chromen-7-yl)oxy)methyl)benzoic acid
  • Synonyms: N/A
  • CAS #: 1005334-57-5
  • PubChem CID: 23661666
  • IUPAC: 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid
  • INCHI Name: InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
  • INCHI Key: YYOOFJZTRCPVFD-UHFFFAOYSA-N
  • Molecular Weight: 465.5
  • Canonical SMILES: CS(=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OCC4=CC(=CC=C4)C(=O)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C24H19NO7S

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: SML1366
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C24H19NO7S 466.0955; found 466.0966

Dose Response Curve

  • Platform ID: CVT-10216
  • Min: -2.3464; Max: 12.4545





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/0ScoresViewViewViewViewView