Table of Contents
RS-1 10μM R08 exp519
Mechanism of Action
Technical Notes
Screen Summary
Screen Results
RS-1 10μM R08 exp519
Mechanism of Action
Activates DNA binding by RAD51
Class / Subclass 1:
DNA Damage, Repair and Replication / Repair Protein Activator
Technical Notes
Compound References
PubChem Name:
3-(Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
Synonyms:
N/A
CAS #:
312756-74-4
PubChem CID:
1039737
IUPAC:
3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
INCHI Name:
InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
INCHI Key:
SWKAVEUTKGKHSR-UHFFFAOYSA-N
Molecular Weight:
524.2
Canonical SMILES:
C1=CC=C(C=C1)CNS(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC=C(C=C3)Br)Br
Isomeric SMILES:
N/A
Molecular Formula:
C20H16Br2N2O3S
Compound Supplier
Supplier Name:
Cayman Chemical
Catalog #:
21037
Lot #:
N/A
Compound Characterization
HRMS (ESI-TOF) m/z:
(M+H)+ Calcd for C20H16Br2N2O3S 522.93212; found 522.93209
Dose Response Curve
Dose response curve not available.
Screen Summary
Round
: 08
Dose
: 10µM
Days of incubation
: 8
Doublings
: 5.6
Numbers of reads
: 16262228
Screen Results
Sensitive/Resistant hits (FDR<0.05)
CRANKS
Score Plot
Top 30 Genes
Screen Similarity
Top 30 Sensitive GO terms
Top 30 Resistant GO terms
0/0
Scores
View
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×
RS-1 10μM R08 exp519
×
Top 30 S/R Genes
Gene
CRANKS Score
FDR
GOT1
-2.68
0.08
AASDHPPT
-2.61
0.08
CSK
-2.58
0.08
LRIG2
-2.51
0.08
SLC38A5
-2.48
0.08
STYX
-2.42
0.20
BCORL1
-2.36
0.20
ZFAND3
-2.34
0.16
UROD
-2.29
0.43
STARD8
-2.25
0.20
GMPPB
-2.23
0.72
GPATCH1
-2.22
0.20
SCAP
-2.19
0.21
UGT1A9
-2.16
0.23
GOLGA8H
-2.14
0.74
LMAN2
-2.13
0.25
CEPT1
-2.12
0.25
SAYSD1
-2.10
0.26
HABP2
-2.09
0.36
C6orf136
-2.09
0.36
UBA3
-2.08
0.50
SLC5A3
-2.05
0.33
OR2T27
-2.04
0.33
SCD
-2.03
0.41
CHAF1A
-2.03
0.72
C20orf24
-1.99
0.36
MYPN
-1.97
0.36
MLYCD
-1.97
0.36
HHLA2
-1.96
0.36
C16orf46
-1.95
0.65
SLC25A3
1.91
0.54
HNRNPAB
1.91
0.54
EIF1
1.91
0.70
CIDEB
1.92
0.54
ATXN1
1.92
0.70
NFYA
1.92
0.70
NDC80
1.93
0.75
COX4I2
1.93
0.54
PRPS1
1.94
0.54
KIF3B
1.96
0.70
SERGEF
1.97
0.54
GLRX3
1.98
0.54
PBX1
2.01
0.54
INTS2
2.04
0.54
PAFAH1B1
2.05
0.76
PRKD3
2.05
0.50
CEP192
2.07
0.60
LACTB
2.08
0.46
BCL2A1
2.10
0.46
MANSC4
2.12
0.45
ACBD3
2.16
0.54
ESAM
2.18
0.36
FAM129B
2.20
0.54
RACGAP1
2.23
0.54
HAT1
2.30
0.32
DPH1
2.33
0.32
PSME3
2.33
0.36
UTP3
2.35
0.36
LIPT1
2.44
0.28
SLC25A19
2.64
0.17
×
Correlated Screens
No correlation data above threshold. (correlation > 0.05)
×
Top 30 sensitive GO terms
No GO term hits below threshold. (FDR <0.05)
×
Top 30 resistant GO terms
No GO term hits below threshold. (FDR <0.05)