ARID3A
Gene Information
- Official Symbol: ARID3A
- Official Name: AT-rich interaction domain 3A
- Aliases and Previous Symbols: N/A
- Entrez ID: 1820
- UniProt: Q99856
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.
Pfam Domains GO Terms
Pfam Domains
| ARID |
GO Terms
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| membrane raft |
| negative regulation of cell cycle phase transition |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| negative regulation of cell cycle process |
| positive regulation of cell cycle |
| chromatin binding |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| intracellular membrane-bounded organelle |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| protein homodimerization activity |
| cell cycle process |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| cell cycle |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6141
- Expression level (log2 read counts): 5.36
Expression Distribution
ARID3A Expression in NALM6 Cells: 5.36
