BUB1B
Gene Information
- Official Symbol: BUB1B
- Official Name: BUB1 mitotic checkpoint serine/threonine kinase B
- Aliases and Previous Symbols: N/A
- Entrez ID: 701
- UniProt: O60566
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Mad3 BUB1 I |
GO Terms
| meiotic sister chromatid cohesion, centromeric |
| centromeric sister chromatid cohesion |
| meiotic sister chromatid segregation |
| meiotic sister chromatid cohesion |
| condensed nuclear chromosome kinetochore |
| meiosis II |
| meiosis II cell cycle process |
| condensed chromosome outer kinetochore |
| anaphase-promoting complex |
| mitotic spindle assembly checkpoint |
| spindle checkpoint |
| mitotic spindle checkpoint |
| spindle assembly checkpoint |
| negative regulation of mitotic metaphase/anaphase transition |
| negative regulation of metaphase/anaphase transition of cell cycle |
| negative regulation of mitotic sister chromatid separation |
| negative regulation of chromosome separation |
| negative regulation of mitotic sister chromatid segregation |
| negative regulation of sister chromatid segregation |
| negative regulation of chromosome segregation |
| negative regulation of mitotic nuclear division |
| negative regulation of nuclear division |
| sister chromatid cohesion |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| chromosome organization involved in meiotic cell cycle |
| regulation of mitotic sister chromatid segregation |
| regulation of sister chromatid segregation |
| anaphase-promoting complex-dependent catabolic process |
| kinetochore |
| condensed chromosome kinetochore |
| meiotic chromosome segregation |
| regulation of chromosome segregation |
| spindle |
| negative regulation of chromosome organization |
| sister chromatid segregation |
| meiotic nuclear division |
| mitotic cell cycle checkpoint |
| microtubule organizing center |
| meiotic cell cycle process |
| regulation of mitotic nuclear division |
| regulation of nuclear division |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| nuclear chromosome segregation |
| meiotic cell cycle |
| negative regulation of cell cycle phase transition |
| protein kinase activity |
| chromosome segregation |
| nuclear division |
| negative regulation of mitotic cell cycle |
| organelle fission |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| proteasomal protein catabolic process |
| regulation of chromosome organization |
| protein serine/threonine kinase activity |
| negative regulation of organelle organization |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| cell division |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| protein catabolic process |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell cycle process |
| cellular macromolecule catabolic process |
| apoptotic process |
| protein phosphorylation |
| cell cycle process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| chromosome organization |
| cell death |
| regulation of cell cycle |
| proteolysis |
| phosphorylation |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| ATP binding |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 719/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 26/28 |
| bone | 25/26 |
| breast | 32/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 2500
- Expression level (log2 read counts): 7.79
Expression Distribution
BUB1B Expression in NALM6 Cells: 7.79
