CD19
Gene Information
- Official Symbol: CD19
- Official Name: CD19 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 930
- UniProt: P15391
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008].
- UniProt Summary: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| B-1 B cell differentiation |
| B cell proliferation involved in immune response |
| mature B cell differentiation |
| regulation of B cell receptor signaling pathway |
| positive regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of lipid kinase activity |
| positive regulation of release of sequestered calcium ion into cytosol |
| B cell proliferation |
| B cell activation involved in immune response |
| positive regulation of phospholipid metabolic process |
| regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of calcium ion transport into cytosol |
| regulation of antigen receptor-mediated signaling pathway |
| regulation of lipid kinase activity |
| positive regulation of calcium ion transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| lymphocyte proliferation |
| regulation of phospholipid metabolic process |
| mononuclear cell proliferation |
| leukocyte proliferation |
| regulation of calcium ion transport into cytosol |
| B cell differentiation |
| lymphocyte activation involved in immune response |
| regulation of complement activation |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| B cell receptor signaling pathway |
| regulation of humoral immune response |
| positive regulation of lipid metabolic process |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| B cell activation |
| positive regulation of ion transmembrane transport |
| positive regulation of protein kinase B signaling |
| positive regulation of transmembrane transport |
| immunoglobulin mediated immune response |
| regulation of B cell activation |
| B cell mediated immunity |
| regulation of protein kinase B signaling |
| membrane raft |
| lymphocyte differentiation |
| regulation of calcium ion transport |
| lymphocyte mediated immunity |
| positive regulation of ion transport |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of cytosolic calcium ion concentration |
| antigen receptor-mediated signaling pathway |
| regulation of cytosolic calcium ion concentration |
| leukocyte differentiation |
| regulation of cation transmembrane transport |
| lymphocyte activation |
| regulation of metal ion transport |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| cellular calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| calcium ion homeostasis |
| regulation of immune effector process |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| immune response-regulating cell surface receptor signaling pathway |
| divalent inorganic cation homeostasis |
| regulation of lymphocyte activation |
| cell population proliferation |
| cellular metal ion homeostasis |
| hemopoiesis |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| positive regulation of kinase activity |
| protein-containing complex |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| leukocyte activation involved in immune response |
| metal ion homeostasis |
| cell activation involved in immune response |
| activation of immune response |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| immune system development |
| positive regulation of transferase activity |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| leukocyte mediated immunity |
| ion homeostasis |
| positive regulation of immune response |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cellular localization |
| leukocyte activation |
| regulation of transferase activity |
| positive regulation of transport |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of phosphorylation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1944
- Expression level (log2 read counts): 8.39
Expression Distribution
CD19 Expression in NALM6 Cells: 8.39
