FZR1
Gene Information
- Official Symbol: FZR1
- Official Name: fizzy and cell division cycle 20 related 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51343
- UniProt: Q9UM11
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| anaphase-promoting complex binding |
| ubiquitin-protein transferase activator activity |
| positive regulation of ubiquitin protein ligase activity |
| signal transduction involved in G2 DNA damage checkpoint |
| anaphase-promoting complex |
| regulation of ubiquitin protein ligase activity |
| negative regulation of cell aging |
| lens fiber cell differentiation |
| G2 DNA damage checkpoint |
| protein K11-linked ubiquitination |
| regulation of meiotic nuclear division |
| positive regulation of ubiquitin-protein transferase activity |
| regulation of cell aging |
| regulation of meiotic cell cycle |
| regulation of ubiquitin-protein transferase activity |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in cell cycle checkpoint |
| lens development in camera-type eye |
| anaphase-promoting complex-dependent catabolic process |
| negative regulation of cell cycle G2/M phase transition |
| signal transduction in response to DNA damage |
| positive regulation of protein ubiquitination |
| DNA damage checkpoint |
| positive regulation of protein modification by small protein conjugation or removal |
| DNA integrity checkpoint |
| regulation of reproductive process |
| regulation of nuclear division |
| cell cycle checkpoint |
| regulation of protein ubiquitination |
| regulation of cell cycle G2/M phase transition |
| positive regulation of protein catabolic process |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cell cycle phase transition |
| nuclear membrane |
| protein polyubiquitination |
| camera-type eye development |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| proteasomal protein catabolic process |
| eye development |
| visual system development |
| sensory system development |
| regulation of protein catabolic process |
| regulation of mitotic cell cycle phase transition |
| positive regulation of catabolic process |
| regulation of cell cycle phase transition |
| cell division |
| DNA repair |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| sensory organ development |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| epithelial cell differentiation |
| protein catabolic process |
| protein ubiquitination |
| DNA metabolic process |
| regulation of cell cycle process |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| epithelium development |
| regulation of cell cycle |
| positive regulation of protein modification process |
| proteolysis |
| regulation of organelle organization |
| cell cycle |
| positive regulation of catalytic activity |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3629
- Expression level (log2 read counts): 5.84
Expression Distribution
FZR1 Expression in NALM6 Cells: 5.84
