G3BP1

Entrez Summary: N/A
UniProt Summary: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:9889278}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.62
3-Bromopyruvate 7μM R04 exp175	-2.44
Aminopterin 0.005μM R07 exp335	-2.36
Docetaxel 0.002μM R01 exp45	-2.29
THZ531 0.225μM R08 exp444	-1.94
Bortezomib 0.005μM R00 exp6	-1.85
Taxol 0.004μM R03 exp103	1.7
Deguelin 0.15μM R05 exp209	1.77
DABN 2μM R00 exp16	1.8
Rapamycin 1μM R00 exp29	1.8
Wortmannin 0.5μM R00 exp37	1.83
Mubritinib 0.2μM R02 exp65	1.84
5-Azacytidine 2μM R07 exp330	1.85
Chlorpromazine 10μM R07 exp344	1.85
I-BRD9 4μM R07 exp365	1.92
QNZ 0.01μM R05 exp241	1.92
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.95
GSK-LSD1 10μM R03 exp123	2.15
Vemurafenib 6.6μM R02 exp89	2.18
Rotenone 0.07μM R08 exp431	2.22
PF-06409577 20μM R07 exp389	2.28
AICAR 240μM R03 exp116	2.33
QNZ 0.01μM R08 exp439	2.45
Phenformin 20μM R05 exp212	2.62
Oligomycin-A 2μM R00 exp25	2.89
Vemurafenib 6.6μM R08 exp434	2.93
TRAIL 5ng/ml R00 exp35	3.15
Chloramphenicol 20μM R00 exp13	3.18
TRAIL 50ng/ml R00 exp36	4.03

Gene	Correlation
ELF1	0.48
TNPO1	0.451

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution