GTF2A2
Gene Information
- Official Symbol: GTF2A2
- Official Name: general transcription factor IIA subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2958
- UniProt: P52657
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}.
Pfam Domains GO Terms
Pfam Domains
| TFIIA gamma C |
| TFIIA gamma N |
GO Terms
| transcription factor TFIIA complex |
| RNA polymerase II preinitiation complex assembly |
| RNA polymerase II general transcription initiation factor activity |
| TBP-class protein binding |
| transcription preinitiation complex assembly |
| RNA polymerase II repressing transcription factor binding |
| transcription factor TFIID complex |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| ncRNA transcription |
| transcription initiation from RNA polymerase II promoter |
| protein-DNA complex assembly |
| DNA-templated transcription, initiation |
| protein-DNA complex subunit organization |
| positive regulation of DNA-binding transcription factor activity |
| transcription coactivator activity |
| transcription factor binding |
| regulation of DNA-binding transcription factor activity |
| transcription by RNA polymerase II |
| protein heterodimerization activity |
| cell junction |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| viral process |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| protein homodimerization activity |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| DPAGT1 | 0.546 |
| THG1L | 0.528 |
| PMM2 | 0.528 |
| RPTOR | 0.5 |
| WDR24 | 0.492 |
| RNMT | 0.489 |
| GMPPB | 0.487 |
| CBFB | 0.485 |
| DOHH | 0.482 |
| SRP14 | 0.474 |
| UTP23 | 0.47 |
| ALG1 | 0.46 |
| LAMTOR4 | 0.46 |
| WDR59 | 0.455 |
| TRIAP1 | 0.449 |
| ALG2 | 0.445 |
| PELO | 0.438 |
| CCDC101 | 0.438 |
| GNB1L | 0.436 |
| UAP1 | 0.434 |
| TRMT10A | 0.432 |
| PPA2 | 0.426 |
| RPIA | 0.425 |
| NAE1 | 0.421 |
| MED16 | 0.42 |
| GTF3C2 | 0.42 |
| ALG13 | 0.418 |
| LSM10 | 0.418 |
| CHCHD4 | 0.416 |
| GFPT1 | 0.415 |
| ADSL | 0.413 |
| UHRF1 | 0.412 |
| SDHA | 0.41 |
| TRMT5 | 0.409 |
| LAMTOR5 | 0.409 |
| RTCB | 0.408 |
| GTF3C3 | 0.408 |
| RPP21 | 0.407 |
| TEN1 | 0.406 |
| SSBP2 | 0.406 |
| FNTA | 0.406 |
| RFT1 | 0.406 |
| VPS41 | 0.405 |
| TAZ | 0.403 |
| UBE2G2 | 0.403 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 693/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 25/28 |
| bone | 24/25 |
| breast | 30/33 |
| central nervous system | 51/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 14/15 |
| kidney | 20/21 |
| liver | 19/20 |
| lung | 73/75 |
| lymphocyte | 13/14 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 13/15 |
| prostate | 1/1 |
| skin | 21/24 |
| soft tissue | 5/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1654
- Expression level (log2 read counts): 6.32
Expression Distribution
GTF2A2 Expression in NALM6 Cells: 6.32
