HSPE1

Gene Information

Official Symbol: HSPE1
Official Name: heat shock protein family E (Hsp10) member 1
Aliases and Previous Symbols: N/A
Entrez ID: 3336
UniProt: P61604
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
UniProt Summary: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-3.03
Cidofovir 10μM R07 exp345	-1.93
Thioridazine 5μM R08 exp530	-1.72
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.72
TRAIL 5ng/ml R00 exp35	1.72
HMS-I2 5μM R06 exp287	1.74
Benzoate 20000μM R08 exp456	1.82
Oligomycin-A 20μM R00 exp26	1.82
Epigallocatechin gallate 20μM R05 exp230	1.85
IWR1 50μM R08 exp495	1.89
GSK591 2.6μM R03 exp128	1.93
Nocodazole 0.1μM R03 exp94	1.93
GSK-J4 1.5μM R08 exp441	1.94
Actinomycin-D 0.001μM R00 exp3	1.98
Rotenone 20μM R00 exp34	1.99
Tanespimycin 14μM R08 exp527	2
Rotenone 2μM R00 exp33	2.01
BI-6727 0.04μM R03 exp98	2.05
AICAR 240μM R03 exp116	2.14
BI-2536 0.02μM R03 exp96	2.19
Ethanol 0.01 R05 exp234	2.2
Caffeine 2600μM R08 exp463	2.21
Azithromycin 100μM R08 exp452	2.31
Demecolcine 0.03μM R05 exp228	2.31
Salubrinal 20μM R07 exp399	2.34
SGC0649 7μM R03 exp150	2.47
Erlotinib 10μM R05 exp216	2.64
Colchicine 0.009μM R05 exp215	2.71

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 87
Expression level (log2 read counts): 7.14

Expression Distribution