MEF2C

Gene Information

Official Symbol: MEF2C
Official Name: myocyte enhancer factor 2C
Aliases and Previous Symbols: N/A
Entrez ID: 4208
UniProt: Q06413
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].
UniProt Summary: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 5μM R05 exp245	-3.29
Lead acetate 2000μM R08 exp497	-2.83
Rapamycin 10μM R00 exp30	-2.63
Rapamycin 1μM R00 exp29	-2.42
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.17
Rapamycin 0.001μM R08 exp429	-2.15
TRAIL 5ng/ml R00 exp35	-2.11
Vemurafenib 6.6μM R08 exp434	-2.11
Pomalidomide 20μM R07 exp391	-2.05
Vemurafenib 6.6μM R02 exp89	-1.95
Wortmannin 0.5μM R00 exp37	-1.95
Temozolomide 200μM R04 exp189	-1.92
Daidzin 10μM R06 exp280	-1.9
LY2090314 0.003μM R08 exp499	-1.9
Hydroxyurea 100μM R07 exp329	-1.77
Lead acetate 2000μM R08 exp498 no dilution day6	-1.77
Thioridazine 5μM R08 exp530	-1.77
All-trans-Retinoic-Acid 8μM R07 exp333	-1.71
UMK57 0.6μM R03 exp107	1.71
UMK57 1μM R01 exp59	1.72
MS023 7μM R03 exp135	1.73
Demecolcine 0.03μM R05 exp228	1.79
BI-6727 0.04μM R03 exp98	1.88
BI-2536 0.0042μM R03 exp95	1.95
BI-6727 0.0125μM R03 exp97	2.05
UM131593 0.2μM R03 exp106	2.51
Mdivi-1 15μM R05 exp217	2.78

Gene	Correlation
ZFX	0.528
MAML1	0.483
IRF2BP2	0.481
XPO6	0.48
ASXL2	0.469
ZNF319	0.448
FLI1	0.446
CTDSPL2	0.441
ID3	0.438
ASB7	0.438
SCAF8	0.418
TRIM33	0.416
ZMYM2	0.411
ERG	0.409
BRPF1	0.409
MED23	0.408
CBFB	0.406
LDB1	0.4

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	3/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	7/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5192
Expression level (log2 read counts): 7.15

Expression Distribution