PPP2R2A
Gene Information
- Official Symbol: PPP2R2A
- Official Name: protein phosphatase 2 regulatory subunit Balpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5520
- UniProt: P63151
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| mitotic nuclear envelope reassembly |
| peptidyl-serine dephosphorylation |
| nuclear envelope reassembly |
| protein phosphatase type 2A complex |
| protein phosphatase 2A binding |
| protein phosphatase regulator activity |
| response to morphine |
| response to isoquinoline alkaloid |
| tau protein binding |
| nuclear envelope organization |
| protein serine/threonine phosphatase activity |
| response to anesthetic |
| response to alkaloid |
| regulation of phosphoprotein phosphatase activity |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| G2/M transition of mitotic cell cycle |
| nucleus organization |
| cell cycle G2/M phase transition |
| regulation of protein dephosphorylation |
| regulation of phosphatase activity |
| response to ammonium ion |
| nuclear-transcribed mRNA catabolic process |
| regulation of dephosphorylation |
| protein dephosphorylation |
| mRNA catabolic process |
| RNA catabolic process |
| protein-containing complex binding |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| response to xenobiotic stimulus |
| dephosphorylation |
| glutamatergic synapse |
| nucleobase-containing compound catabolic process |
| endomembrane system organization |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| mitotic cell cycle process |
| mitotic cell cycle |
| mRNA metabolic process |
| membrane organization |
| cellular macromolecule catabolic process |
| response to organic cyclic compound |
| cell cycle process |
| response to organonitrogen compound |
| response to drug |
| macromolecule catabolic process |
| response to nitrogen compound |
| regulation of hydrolase activity |
| cell cycle |
| RNA metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 22/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 4/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2441
- Expression level (log2 read counts): 6.33
Expression Distribution
PPP2R2A Expression in NALM6 Cells: 6.33
