RPL37A
Gene Information
- Official Symbol: RPL37A
- Official Name: ribosomal protein L37a
- Aliases and Previous Symbols: N/A
- Entrez ID: 6168
- UniProt: P61513
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L37ae |
GO Terms
| cytosolic large ribosomal subunit |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| establishment of protein localization to membrane |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GOLGA6L1 | 0.6 |
| COPE | 0.492 |
| DNTTIP2 | 0.485 |
| RPS19BP1 | 0.46 |
| GAR1 | 0.458 |
| TFIP11 | 0.456 |
| SCGB1C1 | 0.441 |
| ORC1 | 0.435 |
| TCEB3C | 0.433 |
| RPL14 | 0.428 |
| TCF25 | 0.427 |
| SHPK | 0.422 |
| SPATA13 | 0.422 |
| PARP3 | 0.418 |
| TCEB3CL2 | 0.417 |
| PSMD7 | 0.417 |
| TCEB3CL | 0.416 |
| TBC1D3F | 0.41 |
| VPS28 | 0.41 |
| CHAF1A | 0.408 |
| EXD1 | 0.407 |
| CMYA5 | 0.403 |
| AQR | 0.402 |
| POLR2A | 0.402 |
| ZNF335 | 0.401 |
| HIVEP3 | 0.401 |
| CACTIN | 0.401 |
| NOL12 | 0.401 |
| UTP20 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 605/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 22/28 |
| blood | 21/28 |
| bone | 22/26 |
| breast | 26/33 |
| central nervous system | 50/56 |
| cervix | 4/4 |
| colorectal | 13/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 17/21 |
| liver | 15/20 |
| lung | 60/75 |
| lymphocyte | 12/16 |
| ovary | 24/26 |
| pancreas | 19/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 10/15 |
| prostate | 0/1 |
| skin | 16/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 24/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 485
- Expression level (log2 read counts): 9.13
Expression Distribution
RPL37A Expression in NALM6 Cells: 9.13
