SEC16A
Gene Information
- Official Symbol: SEC16A
- Official Name: SEC16 homolog A, endoplasmic reticulum export factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 9919
- UniProt: O15027
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411}.
Pfam Domains GO Terms
Pfam Domains
| Sec16 |
| Sec16 C |
GO Terms
| Golgi to plasma membrane CFTR protein transport |
| protein localization to endoplasmic reticulum exit site |
| organelle membrane |
| positive regulation of protein exit from endoplasmic reticulum |
| protein exit from endoplasmic reticulum |
| regulation of protein exit from endoplasmic reticulum |
| endoplasmic reticulum exit site |
| Golgi to plasma membrane protein transport |
| substantia nigra development |
| establishment of protein localization to plasma membrane |
| ER to Golgi transport vesicle membrane |
| endoplasmic reticulum organization |
| Golgi to plasma membrane transport |
| neural nucleus development |
| COPII vesicle coating |
| vesicle targeting, rough ER to cis-Golgi |
| vesicle coating |
| COPII-coated vesicle budding |
| vesicle targeting, to, from or within Golgi |
| Golgi vesicle budding |
| midbrain development |
| vesicle targeting |
| vesicle-mediated transport to the plasma membrane |
| vesicle budding from membrane |
| post-Golgi vesicle-mediated transport |
| Golgi organization |
| protein localization to endoplasmic reticulum |
| positive regulation of intracellular protein transport |
| establishment of vesicle localization |
| protein stabilization |
| protein localization to plasma membrane |
| vesicle localization |
| positive regulation of intracellular transport |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| protein localization to cell periphery |
| regulation of intracellular protein transport |
| response to endoplasmic reticulum stress |
| establishment of protein localization to membrane |
| regulation of protein stability |
| vesicle organization |
| positive regulation of cellular protein localization |
| regulation of intracellular transport |
| establishment of organelle localization |
| Golgi vesicle transport |
| endomembrane system organization |
| positive regulation of protein transport |
| positive regulation of establishment of protein localization |
| protein localization to membrane |
| regulation of cellular protein localization |
| organelle localization |
| Golgi membrane |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| protein localization to organelle |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| head development |
| membrane organization |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| central nervous system development |
| Golgi apparatus |
| positive regulation of transport |
| intracellular protein transport |
| endoplasmic reticulum |
| regulation of protein localization |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular response to stress |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 62/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 3/28 |
| bone | 5/26 |
| breast | 2/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 3/21 |
| liver | 2/20 |
| lung | 6/75 |
| lymphocyte | 3/16 |
| ovary | 5/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 4848
- Expression level (log2 read counts): 7.67
Expression Distribution
SEC16A Expression in NALM6 Cells: 7.67
