UBE4B
Gene Information
- Official Symbol: UBE4B
- Official Name: ubiquitination factor E4B
- Aliases and Previous Symbols: N/A
- Entrez ID: 10277
- UniProt: O95155
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00}.
Pfam Domains GO Terms
Pfam Domains
| U-box |
| Ufd2P core |
GO Terms
| granzyme-mediated apoptotic signaling pathway |
| ubiquitin-ubiquitin ligase activity |
| ventricular trabecula myocardium morphogenesis |
| heart trabecula morphogenesis |
| trabecula morphogenesis |
| ventricular cardiac muscle tissue morphogenesis |
| ventricular cardiac muscle tissue development |
| protein monoubiquitination |
| protein autoubiquitination |
| cardiac muscle tissue morphogenesis |
| ubiquitin-dependent ERAD pathway |
| cardiac ventricle morphogenesis |
| ATPase binding |
| muscle tissue morphogenesis |
| muscle organ morphogenesis |
| ERAD pathway |
| ubiquitin ligase complex |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| response to UV |
| cardiac muscle tissue development |
| cardiac chamber development |
| heart morphogenesis |
| response to endoplasmic reticulum stress |
| striated muscle tissue development |
| apoptotic signaling pathway |
| muscle organ development |
| muscle tissue development |
| protein polyubiquitination |
| response to light stimulus |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| enzyme binding |
| proteasomal protein catabolic process |
| response to radiation |
| muscle structure development |
| heart development |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| tissue morphogenesis |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| neuron projection development |
| protein catabolic process |
| protein ubiquitination |
| protein modification by small protein conjugation |
| neuron development |
| circulatory system development |
| cellular macromolecule catabolic process |
| apoptotic process |
| animal organ morphogenesis |
| protein modification by small protein conjugation or removal |
| response to organonitrogen compound |
| neuron differentiation |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| cell death |
| plasma membrane bounded cell projection organization |
| response to abiotic stimulus |
| cell projection organization |
| proteolysis |
| ATP binding |
| generation of neurons |
| neurogenesis |
| cell development |
| cellular response to stress |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18477
- Expression level (log2 read counts): 6.04
Expression Distribution
UBE4B Expression in NALM6 Cells: 6.04
