VBP1
Gene Information
- Official Symbol: VBP1
- Official Name: VHL binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7411
- UniProt: P61758
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015].
- UniProt Summary: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13679
- Expression level (log2 read counts): 5.81
VBP1 Expression in NALM6 Cells: 5.81
