VPS41

Gene Information

Official Symbol: VPS41
Official Name: VPS41 subunit of HOPS complex
Aliases and Previous Symbols: N/A
Entrez ID: 27072
UniProt: P49754
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). {ECO:0000250|UniProtKB:D3ZVH6, ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:25445562, ECO:0000269|PubMed:25783203, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:9159129, ECO:0000305|PubMed:23167963, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24210660, ECO:0000305|PubMed:25445562}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PF-06409577 20μM R07 exp389	-1.83
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.8
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.8
proTAME 5μM R04 exp187	-1.78
Wortmannin 0.5μM R00 exp37	-1.73
JQ1 0.8μM R08 exp435	1.72
PU-H71 1μM R08 exp515	1.74
TRAIL 50ng/ml R00 exp36	1.78
ONC212 0.15μM R08 exp513	1.9
LY2090314 0.003μM R08 exp499	2
LY2090314 0.003μM R08 exp500 no dilution day6	2.16
Nocodazole 0.2μM R00 exp24	2.16
Nocodazole 0.1μM R03 exp94	2.29
Vinblastine 0.015μM R05 exp208	2.32
R-DABN 8μM R03 exp111	2.33
Rotenone 2μM R00 exp33	2.92
SB743921 0.001μM R05 exp244	3.05

Gene	Correlation
LAMTOR4	0.568
WDR24	0.527
FLCN	0.494
LAMTOR3	0.487
LAMTOR5	0.484
DOHH	0.478
PPA2	0.471
HGC6.3	0.468
LAMTOR2	0.458
FNIP1	0.454
TEFM	0.448
TBC1D5	0.44
MTMR6	0.426
RPTOR	0.425
MIOS	0.425
TRMT10A	0.422
KDSR	0.422
THG1L	0.419
TRNT1	0.417
EXOC4	0.416
UQCR10	0.415
ALG13	0.413
VPS35	0.411
TBP	0.411
RNMT	0.408
URM1	0.408
WDR59	0.407
VPS26A	0.407
GTF2A2	0.405
LIPA	0.401
TUFM	0.4

Global Fraction of Cell Lines Where Essential: 528/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	24/28
bone	21/26
breast	22/33
central nervous system	24/56
cervix	3/4
colorectal	11/17
esophagus	6/13
fibroblast	1/1
gastric	11/16
kidney	16/21
liver	15/20
lung	57/75
lymphocyte	16/16
ovary	20/26
pancreas	19/24
peripheral nervous system	13/16
plasma cell	14/15
prostate	1/1
skin	10/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	16/22
urinary tract	22/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 6030
Expression level (log2 read counts): 5.83

Expression Distribution