Table of Contents

SB202190 10μM R03 exp148

Mechanism of Action

Inhibits p38‘± (MAPK14)and p38‘_ (MAPK11) kinase, ATP competitive

Technical Notes

Protein References

  • PubChem Name: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
  • Synonyms: N/A
  • CAS #: 152121-30-7
  • PubChem CID: 5169
  • IUPAC: 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
  • INCHI Name: InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
  • INCHI Key: QHKYPYXTTXKZST-UHFFFAOYSA-N
  • Molecular Weight: 331.3
  • Canonical SMILES: C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C20H14FN3O

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1077
  • Lot #: 01

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H14FN3O 332.11937; found 332.11933

Dose Response Curve

  • Platform ID: SB202190
  • Min: 4.3648; Max: 53.7816





IC Concentration (µM)
IC10 N/A
IC20 2.7330
IC30 7.9975
IC40 19.2844
IC50 43.2506
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
2/0ScoresViewViewViewViewView