Table of Contents

Temozolomide 200μM R04 exp189

Mechanism of Action

Alkylates purine bases, prodrug hydrolyzes to 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC)

Technical Notes

Protein References

  • PubChem Name: Temozolomide
  • Synonyms: NSC 362856; CCRG 81045; TMZ; NSC 362856;CCRG 81045;TMZ
  • CAS #: 85622-93-1
  • PubChem CID: 5394
  • IUPAC: 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  • INCHI Name: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
  • INCHI Key: BPEGJWRSRHCHSN-UHFFFAOYSA-N
  • Molecular Weight: 194.15
  • Canonical SMILES: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
  • Isomeric SMILES: N/A
  • Molecular Formula: C6H6N6O2

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1237
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H6N6O2 195.0625; found 195.06203

Dose Response Curve

  • Platform ID: Temozolomide
  • Min: -5.2800; Max: 2.5972





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
14/19ScoresViewViewViewViewView