Table of Contents

Cannabidiol 13μM R08 exp465

Mechanism of Action

Negative allosteric modulator of cannabinoid CB1 receptor

Technical Notes

Protein References

  • PubChem Name: Cannabidiol
  • Synonyms: N/A
  • CAS #: 13956-29-1
  • PubChem CID: 644019
  • IUPAC: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
  • INCHI Name: InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
  • INCHI Key: QHMBSVQNZZTUGM-ZWKOTPCHSA-N
  • Molecular Weight: 314.5
  • Canonical SMILES: CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O
  • Isomeric SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
  • Molecular Formula: C21H30O2

Protein Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: C175300
  • Lot #: 9-RIT-154-2

Protein Characterization

  • LCMS: Tr 1.38 min, m/z 315+ [M+H]+, 313- [M-H]-

Dose Response Curve

  • Platform ID: CBD
  • Min: -4.3129; Max: 99.8419





IC Concentration (µM)
IC10 7.8520
IC20 10.4800
IC30 12.6900
IC40 14.8500
IC50 17.1600
IC60 19.8200
IC70 23.1900
IC80 28.0900
IC90 37.4800


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
12/5ScoresViewViewViewViewView