Table of Contents
RK-33 8μM R08 exp518
Mechanism of Action
Inhibits DDX3 RNA helicase, causes G1 arrest and apoptosis, broad spectrum anti-viral
- Class / Subclass 1: Proteostasis / Translation Inhibitor
- Class / Subclass 2: Infectious Disease / Antiviral
Technical Notes
Protein References
- PubChem Name: 5,11-Bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
- Synonyms: N/A
- CAS #: 1070773-09-9
- PubChem CID: 46184988
- IUPAC: 5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
- INCHI Name: InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
- INCHI Key: COUMZXFUZDBRCZ-UHFFFAOYSA-N
- Molecular Weight: 428.4
- Canonical SMILES: COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
- Isomeric SMILES: N/A
- Molecular Formula: C23H20N6O3
Protein Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-100455
- Lot #: 21870
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H20N6O3 429.16697; found 429.16419
Dose Response Curve
- Platform ID: RK33
- Min: -5.9360; Max: 99.1047
| IC | Concentration (µM) |
|---|---|
| IC10 | 4.0260 |
| IC20 | 5.9440 |
| IC30 | 7.7020 |
| IC40 | 9.5230 |
| IC50 | 11.5700 |
| IC60 | 14.0600 |
| IC70 | 17.3900 |
| IC80 | 22.5300 |
| IC90 | 33.2600 |
Screen Summary
- Round: 08
- Dose: 8µM
- Days of incubation: 8
- Doublings: -0.0
- Numbers of reads: 17248474
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/16 | Scores |
RK-33 8μM R08 exp518
