NUDT5

Entrez Summary: N/A
UniProt Summary: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5- phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy- consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloramphenicol 20μM R00 exp13	-2.91
Rifampicin 10μM R00 exp32	-2.7
Zebularine 20μM R07 exp423	-2.54
Rotenone 0.07μM R08 exp431	-2.5
Nocodazole 0.02μM R00 exp23	-2.49
Phenformin 20μM R05 exp212	-2.41
UM0131023 0.05μM R05 exp248	-2.41
Mubritinib 0.2μM R01 exp48	-2.3
Nifuroxazide 5μM R03 exp102	-2.3
Alpha-Amanitin 0.5μM R00 exp5	-2.18
S-trityl-L-cysteine 0.5μM R05 exp243	-2.14
Hypoxia 5%O2 R04 exp191	-2.12
Chloramphenicol 2μM R00 exp12	-2.12
2-Methoxyestradiol 0.55μM R07 exp310	-2.08
CB-839 10μM R05 exp224	-2.08
DABN 2μM R00 exp16	-2.08
Actinomycin-D 0.001μM R00 exp3	-2.06
Vinorelbine 0.001μM R05 exp249	-1.95
BAY-598 4μM R05 exp220	-1.94
Citral 50μM R06 exp274	-1.94
iCRT14 30μM R08 exp492	-1.91
Nutlin-3A 1.6μM R06 exp294	-1.88
MK2206 4μM R08 exp504	-1.86
Myriocin 25μM R06 exp293	-1.84
Mubritinib 0.2μM R02 exp65	-1.8
Nifuroxazide 1μM R01 exp51	-1.78
Deguelin 0.05μM R02 exp69	-1.76
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.75
QNZ 0.01μM R08 exp439	-1.74
Rifampicin 1μM R00 exp31	-1.74
Rapamycin 10μM R00 exp30	-1.73
Cabazitaxel 0.001μM R05 exp223	-1.72
AICAR 240μM R03 exp116	1.7
CR131-b 0.005μM R08 exp474	1.7
Adefovir 20μM R07 exp332	1.72
ONC212 0.15μM R08 exp513	1.77
ML-792 0.2μM R08 exp505	2
BI-6727 0.0125μM R03 exp97	2.05
BI-2536 0.0042μM R03 exp95	2.48
LY2090314 0.003μM R08 exp499	2.58
Thapsigargin 0.005μM R07 exp407	2.58
CB-5083 0.4μM R08 exp468	2.78
Vemurafenib 6.6μM R02 exp89	2.85
Temozolomide 200μM R04 exp189	2.93
Vemurafenib 6.6μM R08 exp434	3.36
6-Thio-2-deoxyguanosine 2μM R06 exp259	8.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP-sugar diphosphatase activity
8-oxo-dGDP phosphatase activity
D-ribose catabolic process
D-ribose metabolic process
ATP generation from poly-ADP-D-ribose
pentose catabolic process
ribonucleoside diphosphate catabolic process
ADP-ribose diphosphatase activity
nucleoside diphosphate catabolic process
m7G(5)pppN diphosphatase activity
nucleotidyltransferase activity
pentose metabolic process
snoRNA binding
nucleobase-containing small molecule catabolic process
monosaccharide catabolic process
ribonucleoside diphosphate metabolic process
nucleoside phosphate catabolic process
nucleoside diphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
carbohydrate catabolic process
organophosphate catabolic process
chromatin remodeling
monosaccharide metabolic process
ATP metabolic process
magnesium ion binding
ribose phosphate metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
chromatin organization
protein homodimerization activity
organophosphate metabolic process