PPP2R2A

Entrez Summary: N/A
UniProt Summary: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ibrutinib 10μM R08 exp442	-2.43
Cryptotanshinone 12μM R05 exp227	-2.37
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.34
Pyrazinamide 100μM R08 exp516	-2.33
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.32
Arsenate 40μM R06 exp264	-2.24
Tozasertib 0.1μM R07 exp414	-2.23
Cytochalasin-B 5μM R07 exp349	-2.15
Disulfiram 4.3μM R06 exp281	-2.08
Salubrinal 20μM R07 exp399	-2.07
Cyclosporin-A 3μM R07 exp348	-2
THZ531 0.11μM R07 exp409	-2
THZ531 0.225μM R08 exp444	-1.99
Dimethyloxaloylglycine 100μM R05 exp229	-1.96
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.95
MK-1775 0.32μM R02 exp75	-1.93
Ethanol 0.01 R05 exp234	-1.9
Parthenolide 2.5μM R05 exp238	-1.86
Latrunculin-B 10μM R07 exp374	-1.84
Olaparib 4μM R08 exp512	-1.83
Citral 75μM R06 exp275	-1.81
Etoposide 1μM R00 exp19	-1.81
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.76
Apcin 50 to 100μM on day4 R04 exp176	-1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.76
Thioridazine 5μM R08 exp530	-1.73
Colchicine 0.009μM R05 exp215	-1.7
YM155 0.0002μM R01 exp61	1.79
Actinomycin-D 0.01μM R00 exp4	2.19
BI-6727 0.001μM R01 exp42	2.23
Milciclib 2μM R08 exp502	2.44
BVD-523 15μM R02 exp67	2.99

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Expression Distribution

mitotic nuclear envelope reassembly
peptidyl-serine dephosphorylation
nuclear envelope reassembly
protein phosphatase type 2A complex
protein phosphatase 2A binding
protein phosphatase regulator activity
response to morphine
response to isoquinoline alkaloid
tau protein binding
nuclear envelope organization
protein serine/threonine phosphatase activity
response to anesthetic
response to alkaloid
regulation of phosphoprotein phosphatase activity
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G2/M transition of mitotic cell cycle
nucleus organization
cell cycle G2/M phase transition
regulation of protein dephosphorylation
regulation of phosphatase activity
response to ammonium ion
nuclear-transcribed mRNA catabolic process
regulation of dephosphorylation
protein dephosphorylation
mRNA catabolic process
RNA catabolic process
protein-containing complex binding
mitotic cell cycle phase transition
cell cycle phase transition
response to xenobiotic stimulus
dephosphorylation
glutamatergic synapse
nucleobase-containing compound catabolic process
endomembrane system organization
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
mitotic cell cycle process
mitotic cell cycle