UBE2G1

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:20061386}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 0.2μM R00 exp21	-2.64
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.33
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.23
Centrinone 0.5μM R07 exp343	-2.02
Rapamycin 10μM R00 exp30	-1.93
THZ531 0.225μM R08 exp444	-1.88
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.87
EPZ-5676 30μM R05 exp233	-1.72
Nifuroxazide 5μM R03 exp102	-1.7
Rotenone 20μM R00 exp34	1.73
Q15 1 to 2μM on day4 R04 exp164	1.81
Pomalidomide 20μM R07 exp391	1.83
Rotenone 2μM R00 exp33	1.95
Tubastatin-A 2.5μM R07 exp417	1.99
Etoposide 0.3μM R05 exp199	2.05
Pyridostatin 4μM R05 exp240	2.15
UM0011500 5μM R05 exp245	2.22
Etoposide 0.1μM R05 exp198	2.3
Deferoxamine 11μM R07 exp350	2.34
TRAIL 5ng/ml R00 exp35	2.5
Brefeldin A 0.02μM R00 exp8	2.62
Doxorubicin 0.02μM R08 exp478	2.84
UM131593 0.2μM R03 exp106	3.01
5-Fluorouracil 20μM R00 exp2	3.54
Genistein 15μM R07 exp360	3.54
Q15 2.7μM R02 exp79	3.61
Actinomycin-D 0.001μM R00 exp3	3.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein K63-linked ubiquitination
ubiquitin conjugating enzyme activity
protein K48-linked ubiquitination
ubiquitin-protein transferase activity
ubiquitin protein ligase binding
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
ATP binding
organic substance catabolic process
cellular catabolic process