UTY

Official Symbol: UTY
Official Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases and Previous Symbols: N/A
Entrez ID: 7404
UniProt: O14607
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	1.7
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.72
Rapamycin 0.001μM R08 exp429	1.73
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.74
Rapamycin 1μM R00 exp29	1.76
MS023 2μM R03 exp134	1.77
UM0011500 5μM R05 exp245	1.77
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.83
Nicotinamide 2000μM R01 exp50	1.88
MK2206 4μM R08 exp504	1.92
SGC0946 7μM R03 exp151	1.95
Rapamycin 2μM R07 exp306	2.02
Tunicamycin 0.04μM R07 exp418	2.02
Pomalidomide 20μM R07 exp391	2.08
Trichostatin-A 0.06μM R07 exp415	2.13
Arsenic trioxide 60μM R08 exp449	2.18
Chloramphenicol 2μM R00 exp12	2.23
Ethanol 0.01 R05 exp234	2.34
Rapamycin 10μM R00 exp30	2.55

Expression Distribution

JmjC
TPR 1

histone demethylase activity (H3-K27 specific)
histone H3-K27 demethylation
MLL3/4 complex
dioxygenase activity
histone lysine demethylation
histone demethylation
protein demethylation
protein dealkylation
demethylation
chromatin DNA binding
histone modification
covalent chromatin modification
chromatin binding
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
chromatin organization
oxidation-reduction process
chromosome organization