PFI-2 4μM R05 exp239

Mechanism of Action

Inhibits SETD7 lysine methyltransferase (H3K4me)

  • Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Technical Notes

Compound References

  • PubChem Name: 8-Fluoro-N-[(2S)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide;hydrochloride
  • Synonyms: N/A
  • CAS #: 1627607-88-8
  • PubChem CID: 91691132
  • IUPAC: 8-fluoro-N-[(2S)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide;hydrochloride
  • INCHI Name: InChI=1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m0./s1
  • INCHI Key: ZADKZNVAJGEFLC-BOXHHOBZSA-N
  • Molecular Weight: 536
  • Canonical SMILES: C1CCN(C1)C(=O)C(CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F.Cl
  • Isomeric SMILES: C1CCN(C1)C(=O)[C@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F.Cl
  • Molecular Formula: C23H26ClF4N3O3S

Compound Supplier

  • Supplier Name: Structural Genomics Consortium
  • Catalog #: N/A
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H25F4N3O3S 500.16255; found 500.16424

Dose Response Curve

  • Platform ID: PFI2
  • Min: -11.2216; Max: 8.6996





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 05
  • Dose: 4µM
  • Days of incubation: 8
  • Doublings: 7.1
  • Numbers of reads: 13134382

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1