Rifampicin 1μM R00 exp31
Mechanism of Action
Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Rifampicin
- Synonyms: Rifampin; Rifamycin AMP
- CAS #: 13292-46-1
- PubChem CID: 135398735
- IUPAC: [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
- INCHI Name: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
- INCHI Key: JQXXHWHPUNPDRT-WLSIYKJHSA-N
- Molecular Weight: 822.9
- Canonical SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
- Isomeric SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
- Molecular Formula: C43H58N4O12
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-B0272
- Lot #: 33587
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C43H58N4O12 823.4124; found 823.4128
Dose Response Curve
- Platform ID: Rifampicin
- Min: -17.8934; Max: 5.5857
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 00
- Dose: 1µM
- Days of incubation: 8
- Doublings: 6.4
- Numbers of reads: 11435445
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Rifampicin 1μM R00 exp31
Pimelic-diphenylamide-106 0.5μM R00 exp27 vs Rifampicin 1μM R00 exp31
Cycloheximide 0.2μM R00 exp15 vs Rifampicin 1μM R00 exp31
Chloramphenicol 2μM R00 exp12 vs Rifampicin 1μM R00 exp31
Alpha-Amanitin 0.5μM R00 exp5 vs Rifampicin 1μM R00 exp31
CCCP 0.1μM R00 exp10 vs Rifampicin 1μM R00 exp31
Prochlorperazine 5.2μM R02 exp77 vs Rifampicin 1μM R00 exp31
