Lenalidomide 20μM R07 exp375 [The Human Chemical-Genetic Interaction Map Project]

IMiD that targets IKZF1/3 for ubiquitination by CUL4-cereblon complex

Class / Subclass 1: Proteostasis / Bivalent Ligand

Compound References

PubChem Name: Lenalidomide
Synonyms: CC-5013
CAS #: 191732-72-6
PubChem CID: 216326
IUPAC: 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
INCHI Name: InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
INCHI Key: GOTYRUGSSMKFNF-UHFFFAOYSA-N
Molecular Weight: 259.26
Canonical SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Isomeric SMILES: N/A
Molecular Formula: C13H13N3O3

Compound Supplier

Supplier Name: Tocris Bioscience
Catalog #: 6305
Lot #: 1A/208763

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C13H13N3O3 260.10297; found 260.10235

Dose Response Curve

Platform ID: rac-Lenalidomide
Min: -12.7941; Max: 12.6820

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 20µM
Days of incubation: 8
Doublings: 7.2
Numbers of reads: 23498290

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
NSD1	-2.89	0.11
RTCB	-2.57	0.14
ABCG5	-2.56	0.13
ZNF165	-2.48	0.13
KCNS2	-2.45	0.30
ZSCAN12	-2.43	0.51
TXNL4B	-2.39	0.14
GTF2A2	-2.31	0.48
HS3ST1	-2.24	0.28
IGDCC4	-2.22	0.28
OIP5	-2.19	0.29
GPR179	-2.18	0.46
HSPA4	-2.15	0.47
ATP13A3	-2.11	0.48
PTCH1	-2.08	0.48
TPM3	-2.06	0.46
MRPS33	-2.03	0.48
VEZT	-2.02	0.47
TMEM41B	-1.98	0.48
C7orf55-LUC7L2	-1.96	0.48
AADACL4	-1.96	0.48
BMX	-1.95	0.48
PMM2	-1.94	0.48
NPRL3	-1.94	0.58
ASB3	-1.93	0.53
OSBPL3	-1.92	0.48
CRCP	-1.91	0.53
TRIAP1	-1.89	0.55
SYNCRIP	-1.88	0.60
ANO5	-1.87	0.48
CNTLN	1.94	0.48
PTPN5	1.94	0.48
EPHA5	1.96	0.48
PDE4D	1.96	0.63
EIF6	1.98	0.73
NPAT	2.04	0.39
SPAG17	2.05	0.39
ETF1	2.06	0.48
CLCN2	2.07	0.39
TSPY8	2.07	0.79
ACIN1	2.09	0.48
RPS8	2.11	0.75
ARCN1	2.13	0.60
ZNF93	2.15	0.39
C18orf8	2.15	0.39
NUDCD1	2.16	0.39
KIAA1211	2.16	0.73
CKAP5	2.17	0.73
SREK1	2.17	0.39
TMSB15B	2.19	0.76
STIL	2.20	0.39
TOP1MT	2.20	0.39
GPX5	2.24	0.39
MFSD9	2.34	0.39
PLEKHA2	2.36	0.39
PLRG1	2.38	0.39
TUBB4A	2.44	0.39
CROCC	2.49	0.39
NPIPB3	2.61	0.76
DHX38	2.69	0.39

Last modified: 2026/01/15 21:36
by 127.0.0.1