CyclicAMP 200μM R08 exp475
Mechanism of Action
Second messenger, activates PKA, ion channels, cyclic nucleotide-binding proteins
- Class / Subclass 1: Metabolism / Metabolite
- Class / Subclass 2: Signal Transduction / Kinase Activator
Technical Notes
Compound References
- PubChem Name: Cyclic AMP
- Synonyms: Adenosine 3',5'-cyclophosphate; Cyclic 3',5'-monophosphate adenosine; Cyclic AMP; Adenosine 3',5'-cyclophosphate; Cyclic 3',5'-monophosphate adenosine; Cyclic AMP
- CAS #: 60-92-4
- PubChem CID: 6076
- IUPAC: (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
- INCHI Name: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
- INCHI Key: IVOMOUWHDPKRLL-KQYNXXCUSA-N
- Molecular Weight: 329.21
- Canonical SMILES: C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O
- Isomeric SMILES: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O
- Molecular Formula: C10H12N5O6P
Compound Supplier
- Supplier Name: Combi-Blocks
- Catalog #: QB-1283
- Lot #: B78133
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C10H12N5O6P 330.0598; found 330.05915
Dose Response Curve
- Platform ID: cAMP
- Min: 6.4062; Max: 96.7733
| IC | Concentration (µM) |
|---|---|
| IC10 | 104.8000 |
| IC20 | 145.7000 |
| IC30 | 181.3000 |
| IC40 | 217.0000 |
| IC50 | 255.8000 |
| IC60 | 301.7000 |
| IC70 | 361.0000 |
| IC80 | 449.4000 |
| IC90 | 624.8000 |
Screen Summary
- Round: 08
- Dose: 200µM
- Days of incubation: 8
- Doublings: 6.2
- Numbers of reads: 14430295
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 2/5 | Scores |
CyclicAMP 200μM R08 exp475
