Trametinib 10μM R02 exp83

Mechanism of Action

Inhibits MEK1 and MEK2, reversible allosteric mechanism, used in combination with BRAF V600E inhibitors

  • Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Technical Notes

Compound References

  • PubChem Name: Trametinib
  • Synonyms: GSK1120212; JTP-74057
  • CAS #: 871700-17-3
  • PubChem CID: 11707110
  • IUPAC: N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
  • INCHI Name: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
  • INCHI Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
  • Molecular Weight: 615.4
  • Canonical SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
  • Isomeric SMILES: N/A
  • Molecular Formula: C26H23FIN5O4

Compound Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S2673
  • Lot #: S267306

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C26H23FIN5O4 616.08515; found 616.08594

Dose Response Curve

  • Platform ID: GSK1120212
  • Min: -14.6969; Max: 3.8984





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 02
  • Dose: 10µM
  • Days of incubation: 8
  • Doublings: 6.0
  • Numbers of reads: 12205762

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
5/2ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1