PACS1

Entrez Summary: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-2.89
Dihydrosphingosine 8μM R08 exp476	-2.29
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.04
Cadmium 60μM R08 exp462	-2
Etoposide 1μM R00 exp19	-1.86
TIC10 10μM R08 exp532	-1.8
Hydroxyurea 100μM R07 exp329	-1.78
Parthenolide 2.5μM R05 exp238	1.82
SGC0946 7μM R03 exp151	1.83
MS023 7μM R03 exp135	1.84
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.89
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.89
LY2090314 0.003μM R08 exp499	1.89
Thapsigargin 0.005μM R07 exp407	1.89
Dimethyl-Sulfoxide 1pc R03 exp120	1.95
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.98
Pyridostatin 4μM R05 exp240	1.99
Salinomycin 3.5μM R08 exp521	1.99
3-Bromopyruvate 7μM R04 exp175	2.24
Docetaxel 0.002μM R01 exp45	2.26
Nutlin-3A 1.6μM R06 exp294	2.29
LB-100 4.1μM R02 exp72	2.38
Hippuristanol 0.12μM R08 exp488	2.61
Vincristine 0.0005μM R04 exp190	2.66
Ethanol 0.01 R05 exp234	2.67
Olaparib 4μM R08 exp512	2.82
LB-100 2μM R05 exp210	2.93
MS023 2μM R03 exp134	3.44

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
WDR37	0.576
CD19	0.411

COPI-coated vesicle
protein localization to Golgi apparatus
regulation of defense response to virus by virus
ion channel binding
protein localization to plasma membrane
protein localization to cell periphery
protein localization to membrane
viral process
protein localization to organelle
symbiotic process
interspecies interaction between organisms
Golgi apparatus
cellular protein localization
cellular macromolecule localization