GPS2
Gene Information
- Official Symbol: GPS2
- Official Name: G protein pathway suppressor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2874
- UniProt: Q13227
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:8943324}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of protein K63-linked ubiquitination |
| negative regulation of B cell receptor signaling pathway |
| negative regulation of protein polyubiquitination |
| positive regulation of peroxisome proliferator activated receptor signaling pathway |
| regulation of protein K63-linked ubiquitination |
| GTPase inhibitor activity |
| regulation of peroxisome proliferator activated receptor signaling pathway |
| positive regulation of cholesterol efflux |
| response to mitochondrial depolarisation |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| regulation of protein polyubiquitination |
| positive regulation of cholesterol transport |
| regulation of cholesterol efflux |
| positive regulation of sterol transport |
| regulation of B cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| inactivation of MAPK activity |
| cyclin binding |
| negative regulation of JNK cascade |
| negative regulation of toll-like receptor signaling pathway |
| regulation of cholesterol transport |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of fat cell differentiation |
| regulation of sterol transport |
| negative regulation of GTPase activity |
| transcriptional repressor complex |
| regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of cytokine-mediated signaling pathway |
| positive regulation of lipid transport |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| regulation of toll-like receptor signaling pathway |
| negative regulation of protein ubiquitination |
| negative regulation of MAP kinase activity |
| JNK cascade |
| positive regulation of lipid localization |
| negative regulation of protein modification by small protein conjugation or removal |
| stress-activated MAPK cascade |
| B cell differentiation |
| regulation of lipid transport |
| regulation of fat cell differentiation |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of inflammatory response |
| regulation of lipid localization |
| stress-activated protein kinase signaling cascade |
| B cell activation |
| regulation of cytokine-mediated signaling pathway |
| negative regulation of MAPK cascade |
| regulation of response to cytokine stimulus |
| regulation of JNK cascade |
| regulation of protein ubiquitination |
| negative regulation of defense response |
| negative regulation of protein kinase activity |
| regulation of protein modification by small protein conjugation or removal |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| transcription corepressor activity |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| transcription coactivator activity |
| leukocyte differentiation |
| regulation of inflammatory response |
| regulation of MAP kinase activity |
| negative regulation of response to external stimulus |
| MAPK cascade |
| lymphocyte activation |
| signal transduction by protein phosphorylation |
| regulation of lipid metabolic process |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of innate immune response |
| negative regulation of hydrolase activity |
| regulation of GTPase activity |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| hematopoietic or lymphoid organ development |
| immune system development |
| viral process |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| leukocyte activation |
| negative regulation of developmental process |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of transport |
| negative regulation of cellular protein metabolic process |
| cell activation |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TSC1 | 0.413 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10574
- Expression level (log2 read counts): 5.45
Expression Distribution
GPS2 Expression in NALM6 Cells: 5.45
