KEAP1

Gene Information

Official Symbol: KEAP1
Official Name: kelch like ECH associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9817
UniProt: Q14145
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.75
Lead acetate 2000μM R08 exp498 no dilution day6	-2.72
Taxol 0.004μM R03 exp103	-2.6
Radicicol 0.16μM R05 exp242	-2.55
Lead acetate 2000μM R08 exp497	-2.4
LY2090314 0.003μM R08 exp499	-2.32
Tozasertib 0.1μM R07 exp414	-2.28
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.26
Sulforaphane 9μM R08 exp526 no dilution day6	-2.25
iCRT14 30μM R08 exp492	-2.2
Thapsigargin 0.005μM R07 exp407	-2.12
AICAR 240μM R03 exp116	-2.09
FK-506 30μM R07 exp359	-2.06
Phenformin 20μM R05 exp212	-1.98
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.93
LJH685 5μM R02 exp73	-1.93
LB-100 4.1μM R02 exp72	-1.92
Cabazitaxel 0.001μM R05 exp223	-1.84
Tenofovir 10μM R07 exp405	-1.83
Dexamethasone 0.006μM R07 exp351	-1.8
Parthenolide 2.5μM R05 exp238	-1.79
Sulforaphane 9μM R08 exp525	-1.79
Apcin 50 to 100μM on day4 R04 exp176	-1.77
LB-100 2μM R05 exp210	-1.77
Golgicide-A 4μM R03 exp122	-1.76
Clomiphene 4.4μM R02 exp68	-1.75
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.74
5-Azacytidine 2μM R07 exp330	-1.71
UM0129480 7μM R02 exp85	-1.7
Dynasore 7μM R08 exp436	1.78
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.78
Epigallocatechin gallate 20μM R05 exp230	1.87
Thimerosal 0.85μM R08 exp529	2.43
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.46
Arsenic trioxide 60μM R08 exp449	4.24

Global Fraction of Cell Lines Where Essential: 26/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	6/33
central nervous system	1/56
cervix	2/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16203
Expression level (log2 read counts): 6.18

Expression Distribution

Kelch 2
Kelch 1
BTB
BACK

cytoplasmic sequestering of transcription factor
cytoplasmic sequestering of protein
proteasomal ubiquitin-independent protein catabolic process
cellular response to interleukin-4
response to interleukin-4
disordered domain specific binding
Cul3-RING ubiquitin ligase complex
regulation of epidermal cell differentiation
actin filament
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of epidermis development
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
maintenance of protein location
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of epithelial cell differentiation
regulation of ubiquitin-dependent protein catabolic process
microtubule organizing center
midbody
negative regulation of DNA-binding transcription factor activity
maintenance of location
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
protein deubiquitination
protein modification by small protein removal
transcription factor binding
proteasomal protein catabolic process
positive regulation of proteolysis
post-translational protein modification
positive regulation of cellular catabolic process
in utero embryonic development
regulation of protein catabolic process
regulation of DNA-binding transcription factor activity
positive regulation of catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process