AHCY

Entrez Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
UniProt Summary: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. {ECO:0000269|PubMed:12590576}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.68
Cycloheximide 0.2μM R00 exp15	-2.5
Ribavirin 10μM R01 exp52	-2.25
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.12
Cabazitaxel 0.001μM R05 exp223	-2.09
2-Methoxyestradiol 0.2μM R01 exp40	-2.08
A-395N 10μM R05 exp219	-2.08
Chloramphenicol 2μM R00 exp12	-1.99
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.89
Arsenate 40μM R06 exp264	-1.87
Geldanamycin 0.01μM R05 exp235	-1.85
Ethambutol 25μM R08 exp481	-1.81
UM0125461 0.74μM R02 exp84	-1.72
Bafilomycin-A1 0.009μM R08 exp454	-1.71
Senexin-A 25μM R07 exp400	1.75
MLN-4924 2μM R00 exp22	1.85

Global Fraction of Cell Lines Where Essential: 299/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	19/28
bone	8/26
breast	22/33
central nervous system	11/56
cervix	3/4
colorectal	4/17
esophagus	4/13
fibroblast	0/1
gastric	10/16
kidney	7/21
liver	6/20
lung	23/75
lymphocyte	10/16
ovary	6/26
pancreas	12/24
peripheral nervous system	4/16
plasma cell	12/15
prostate	0/1
skin	8/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	6/22
urinary tract	11/29
uterus	1/5

Expression Distribution

adenyl nucleotide binding
S-adenosylhomocysteine catabolic process
chronic inflammatory response to antigenic stimulus
adenosylhomocysteinase activity
S-adenosylhomocysteine metabolic process
circadian sleep/wake cycle
S-adenosylmethionine cycle
purine ribonucleoside catabolic process
purine nucleoside catabolic process
chronic inflammatory response
S-adenosylmethionine metabolic process
circadian behavior
ribonucleoside catabolic process
inflammatory response to antigenic stimulus
rhythmic behavior
one-carbon metabolic process
cellular modified amino acid catabolic process
nucleoside catabolic process
NAD binding
sulfur amino acid metabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
sulfur compound catabolic process
cofactor catabolic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
ribonucleoside metabolic process
melanosome
alpha-amino acid catabolic process
nucleoside metabolic process
cellular amino acid catabolic process
glycosyl compound metabolic process
circadian rhythm
carbohydrate derivative catabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
response to nutrient
coenzyme metabolic process
carboxylic acid catabolic process