ATXN2L

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.001μM R00 exp3	-2.58
5-Fluorouracil 20μM R00 exp2	-2.5
Rapamycin 10μM R00 exp30	-2.39
Etoposide 10μM R00 exp20	-2.02
Torin1 0.08μM R02 exp82	-1.92
Rapamycin 1μM R00 exp29	-1.9
Trametinib 10μM R02 exp83	-1.86
MLN-4924 2μM R00 exp22	-1.83
Arsenate 40μM R06 exp264	-1.72
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Lead acetate 2000μM R08 exp497	1.72
TRAIL 5ng/ml R00 exp35	1.74
GSK-J4 1-1.25μM to day4 R07 exp363	1.81
3-Bromopyruvate 7μM R04 exp175	1.86
Isoniazid 100μM R08 exp494	1.89
Artemisinin 50μM R08 exp450	1.9
All-trans-Retinoic-Acid 40μM R07 exp334	1.93
Hydroxyurea 100μM R07 exp329	2.07
Nicotinamide Riboside 100μM R03 exp139	2.11
Deferoxamine 11μM R07 exp350	2.23
TRAIL 50ng/ml R00 exp36	2.24
Diepoxybutane 3μM R07 exp354	2.37
Aminopterin 0.005μM R07 exp335	2.47
Olaparib 4μM R08 exp512	2.65
RK-33 8μM R08 exp518	2.86
2-Deoxy-D-glucose 800μM R05 exp214	4.1
Bortezomib 0.005μM R00 exp6	5.35

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
LSM12	0.665
CDK6	0.4

regulation of cytoplasmic mRNA processing body assembly
stress granule assembly
cytoplasmic stress granule
regulation of organelle assembly
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
cadherin binding
nuclear speck
regulation of protein complex assembly
ribonucleoprotein complex biogenesis
organelle assembly
cellular protein-containing complex assembly
regulation of cellular component biogenesis
regulation of organelle organization
RNA binding
protein-containing complex assembly
protein-containing complex subunit organization
membrane