AURKB
Gene Information
- Official Symbol: AURKB
- Official Name: aurora kinase B
- Aliases and Previous Symbols: N/A
- Entrez ID: 9212
- UniProt: Q96GD4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| histone H3-S28 phosphorylation |
| mitotic cytokinesis checkpoint |
| histone serine kinase activity |
| chromosome passenger complex |
| abscission |
| cleavage furrow formation |
| negative regulation of cytokinesis |
| mitotic spindle midzone assembly |
| condensed chromosome, centromeric region |
| mitotic spindle elongation |
| spindle elongation |
| spindle midzone assembly |
| histone-serine phosphorylation |
| negative regulation of B cell apoptotic process |
| chromocenter |
| condensed nuclear chromosome, centromeric region |
| mitotic spindle midzone |
| protein localization to kinetochore |
| spindle pole centrosome |
| regulation of B cell apoptotic process |
| negative regulation of cell division |
| protein localization to chromosome, centromeric region |
| positive regulation of telomere capping |
| attachment of spindle microtubules to kinetochore |
| spindle checkpoint |
| mitotic spindle assembly checkpoint |
| spindle assembly checkpoint |
| mitotic spindle checkpoint |
| negative regulation of mitotic metaphase/anaphase transition |
| spindle midzone |
| negative regulation of metaphase/anaphase transition of cell cycle |
| regulation of telomere capping |
| negative regulation of mitotic sister chromatid separation |
| negative regulation of chromosome separation |
| negative regulation of lymphocyte apoptotic process |
| histone phosphorylation |
| protein serine/threonine/tyrosine kinase activity |
| negative regulation of mitotic sister chromatid segregation |
| negative regulation of sister chromatid segregation |
| negative regulation of chromosome segregation |
| positive regulation of telomere maintenance via telomerase |
| positive regulation of telomerase activity |
| cytokinetic process |
| spindle microtubule |
| positive regulation of telomere maintenance via telomere lengthening |
| mitotic spindle assembly |
| positive regulation of cytokinesis |
| negative regulation of mitotic nuclear division |
| negative regulation of leukocyte apoptotic process |
| negative regulation of nuclear division |
| positive regulation of telomere maintenance |
| regulation of telomerase activity |
| regulation of mitotic metaphase/anaphase transition |
| regulation of lymphocyte apoptotic process |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of telomere maintenance via telomerase |
| regulation of mitotic sister chromatid separation |
| regulation of telomere maintenance via telomere lengthening |
| protein localization to chromosome |
| regulation of chromosome separation |
| positive regulation of DNA biosynthetic process |
| regulation of mitotic sister chromatid segregation |
| mitotic spindle organization |
| regulation of sister chromatid segregation |
| anaphase-promoting complex-dependent catabolic process |
| regulation of leukocyte apoptotic process |
| regulation of telomere maintenance |
| cellular response to UV |
| kinetochore |
| positive regulation of cell division |
| negative regulation of G2/M transition of mitotic cell cycle |
| regulation of cytokinesis |
| kinase binding |
| cytoskeleton-dependent cytokinesis |
| cytokinesis |
| spindle assembly |
| negative regulation of cell cycle G2/M phase transition |
| regulation of chromosome segregation |
| negative regulation of protein binding |
| microtubule cytoskeleton organization involved in mitosis |
| mitotic sister chromatid segregation |
| regulation of DNA biosynthetic process |
| cellular response to light stimulus |
| spindle |
| negative regulation of chromosome organization |
| plasma membrane invagination |
| sister chromatid segregation |
| response to UV |
| membrane invagination |
| mitotic nuclear division |
| mitotic cell cycle checkpoint |
| spindle organization |
| midbody |
| regulation of cell division |
| regulation of mitotic nuclear division |
| negative regulation of binding |
| positive regulation of chromosome organization |
| cellular response to radiation |
| peptidyl-serine phosphorylation |
| regulation of signal transduction by p53 class mediator |
| regulation of nuclear division |
| cell cycle checkpoint |
| protein autophosphorylation |
| positive regulation of DNA metabolic process |
| regulation of G2/M transition of mitotic cell cycle |
| peptidyl-serine modification |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| regulation of protein binding |
| nuclear chromosome segregation |
| negative regulation of cell cycle phase transition |
| chromosome segregation |
| aging |
| nuclear division |
| positive regulation of cell cycle process |
| response to light stimulus |
| negative regulation of mitotic cell cycle |
| organelle fission |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of chromosome organization |
| proteasomal protein catabolic process |
| regulation of DNA metabolic process |
| protein serine/threonine kinase activity |
| histone modification |
| negative regulation of organelle organization |
| covalent chromatin modification |
| regulation of binding |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| response to radiation |
| regulation of cell cycle phase transition |
| microtubule cytoskeleton organization |
| cell division |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| cell population proliferation |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| microtubule-based process |
| protein catabolic process |
| mitotic cell cycle |
| chromatin organization |
| negative regulation of cellular component organization |
| protein localization to organelle |
| regulation of cell cycle process |
| organelle assembly |
| membrane organization |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| protein phosphorylation |
| regulation of transferase activity |
| negative regulation of cell death |
| cell cycle process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| chromosome organization |
| cytoskeleton organization |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell death |
| negative regulation of gene expression |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 718/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/25 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 15/15 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 14/14 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 7/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 222
- Expression level (log2 read counts): 6.48
Expression Distribution
AURKB Expression in NALM6 Cells: 6.48
