CDC25A

Gene Information

Official Symbol: CDC25A
Official Name: cell division cycle 25A
Aliases and Previous Symbols: N/A
Entrez ID: 993
UniProt: P30304
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TGF-beta1 44ng/ml R08 exp528	-2.27
Senexin-A 25μM R07 exp400	-2.14
Colchicine 0.009μM R05 exp215	-1.98
HMS-I1 1μM R01 exp46	-1.87
RO-3307 4.7μM R02 exp80	-1.84
Taxol 0.004μM R03 exp103	-1.81
BI-2536 0.0042μM R03 exp95	-1.72
Quercetin 20μM R08 exp517	-1.7
SGC0946 7μM R03 exp151	-1.7
Golgicide-A 2μM R03 exp121	1.71
Wiskostatin 3μM R07 exp422	1.72
Dynasore 10μM R04 exp180	1.83
42°C R08 exp539	1.88
GSK626616 14μM R08 exp485	1.88
GW501516 25μM R06 exp285	1.88
Pterostilbene 16μM R02 exp78	2.52

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2831
Expression level (log2 read counts): 6.51

Expression Distribution

Rhodanese
M-inducer phosp

regulation of G2/MI transition of meiotic cell cycle
positive regulation of G2/MI transition of meiotic cell cycle
positive regulation of meiotic cell cycle phase transition
regulation of meiotic cell cycle phase transition
positive regulation of meiotic cell cycle
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
phosphoprotein phosphatase activity
regulation of meiotic cell cycle
positive regulation of mitotic cell cycle phase transition
positive regulation of reproductive process
cellular response to UV
positive regulation of cell cycle phase transition
regulation of cyclin-dependent protein serine/threonine kinase activity
protein tyrosine phosphatase activity
chaperone binding
regulation of cyclin-dependent protein kinase activity
peptidyl-tyrosine dephosphorylation
cellular response to light stimulus
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
response to UV
positive regulation of mitotic cell cycle
regulation of reproductive process
cellular response to radiation
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
protein dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
protein deubiquitination
positive regulation of cell cycle process
protein modification by small protein removal
response to light stimulus
dephosphorylation
cellular response to abiotic stimulus
cellular response to environmental stimulus
positive regulation of cell cycle