CDK12

Entrez Summary: N/A
UniProt Summary: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 9/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Expression Distribution

Pkinase
Pkinase Tyr

cyclin K-CDK12 complex
nuclear cyclin-dependent protein kinase holoenzyme complex
phosphorylation of RNA polymerase II C-terminal domain
cyclin/CDK positive transcription elongation factor complex
positive regulation of transcription elongation from RNA polymerase II promoter
RNA polymerase II CTD heptapeptide repeat kinase activity
negative regulation of stem cell differentiation
cyclin-dependent protein serine/threonine kinase activity
cyclin binding
regulation of transcription elongation from RNA polymerase II promoter
cyclin-dependent protein kinase holoenzyme complex
positive regulation of DNA-templated transcription, elongation
regulation of DNA-templated transcription, elongation
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
regulation of stem cell differentiation
chromosome
fibrillar center
regulation of RNA splicing
protein autophosphorylation
transcription regulatory region DNA binding
nuclear chromatin
protein kinase activity
transcription factor binding
regulation of MAP kinase activity
RNA splicing
nuclear speck
protein kinase binding
mRNA processing
transcription by RNA polymerase II
regulation of protein serine/threonine kinase activity
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
negative regulation of cell differentiation
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
RNA processing