DPH3

Entrez Summary: N/A
UniProt Summary: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Diepoxybutane 3μM R07 exp354	-2.25
UMK57 1μM R01 exp59	-1.86
Dinaciclib 0.007μM R07 exp355	-1.8
L-74142 5μM R03 exp131	-1.73
Bisphenol A 100μM R06 exp269	1.71
Cytochalasin-B 5μM R07 exp349	1.71
ML-792 0.2μM R08 exp505	1.72
CR131-b 0.005μM R08 exp474	1.76
Nocodazole 0.2μM R02 exp64	1.76
BVD-523 15μM R02 exp67	1.85
MLN-4924 0.2μM R00 exp21	1.93
iCRT14 30μM R08 exp492	1.94
Salubrinal 20μM R07 exp399	1.98
Hypoxia 5%O2 R04 exp191	1.99
BI-6727 0.04μM R03 exp98	2.15
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.31
Mubritinib 0.2μM R02 exp65	2.36
GSK-J4 1-1.25μM to day4 R07 exp363	2.49
2-Deoxy-D-glucose 800μM R05 exp214	2.52
AICAR 240μM R03 exp116	2.68
FK-506 30μM R07 exp359	2.71
Hippuristanol 0.12μM R08 exp488	3.16
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.17
MS023 7μM R03 exp135	3.73
MS023 2μM R03 exp134	3.77
UM0129480 7μM R02 exp85	4.57

Global Fraction of Cell Lines Where Essential: 576/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	19/28
blood	15/28
bone	22/26
breast	23/33
central nervous system	49/56
cervix	3/4
colorectal	13/17
esophagus	10/13
fibroblast	1/1
gastric	12/16
kidney	21/21
liver	16/20
lung	52/75
lymphocyte	11/16
ovary	19/26
pancreas	21/24
peripheral nervous system	14/16
plasma cell	6/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	1/2
upper aerodigestive	19/22
urinary tract	26/29
uterus	3/5

Expression Distribution

peptidyl-diphthamide biosynthetic process from peptidyl-histidine
peptidyl-diphthamide metabolic process
peptidyl-histidine modification
regulation of cytoplasmic translational elongation
tRNA wobble uridine modification
regulation of translational elongation
tRNA wobble base modification
regulation of cytoplasmic translation
tRNA modification
tRNA processing
negative regulation of protein secretion
negative regulation of peptide secretion
RNA modification
positive regulation of binding
negative regulation of protein transport
negative regulation of establishment of protein localization
tRNA metabolic process
negative regulation of secretion by cell
negative regulation of secretion
regulation of translation
regulation of binding
ncRNA processing
regulation of cellular amide metabolic process
regulation of protein secretion
ncRNA metabolic process
negative regulation of transport
regulation of peptide secretion
posttranscriptional regulation of gene expression
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
RNA processing
peptidyl-amino acid modification
regulation of protein localization
RNA metabolic process
positive regulation of molecular function
regulation of transport
gene expression