ETFB

Entrez Summary: This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). {ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:25416781, ECO:0000269|PubMed:7912128, ECO:0000269|PubMed:8962055, ECO:0000303|PubMed:17941859, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 3.15μM R02 exp66	-2.38
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.1
42°C R08 exp539	-2.02
Bortezomib 0.005μM R00 exp6	-1.98
MLN-4924 0.2μM R00 exp21	-1.87
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.75
Clomiphene 4.4μM R02 exp68	-1.73
Chloramphenicol 2μM R00 exp12	1.72
CHIR-124 0.04μM R06 exp272	1.73
Trimetrexate 0.03μM R08 exp535	1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.84
Adefovir 20μM R07 exp332	1.96
Caffeine 2600μM R08 exp463	2.02
Tunicamycin 0.04μM R07 exp418	2.22
ETC-159 50μM R08 exp480	2.47

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fatty acid beta-oxidation using acyl-CoA dehydrogenase
fatty acid beta-oxidation
electron transfer activity
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
respiratory electron transport chain
monocarboxylic acid catabolic process
cellular respiration
electron transport chain
cellular lipid catabolic process
lipid modification
energy derivation by oxidation of organic compounds
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
fatty acid metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process