FNIP1

Gene Information

Official Symbol: FNIP1
Official Name: folliculin interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 96459
UniProt: Q8TF40
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353). {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-2.23
KU-0063794 3.8μM R02 exp71	-1.93
Cidofovir 10μM R07 exp345	-1.8
VE-822 0.04μM R06 exp300	-1.73
MS094 2μM R03 exp136	-1.71
3-Bromopyruvate 7μM R04 exp175	1.88
CR131-b 0.005μM R08 exp474	1.98
TRAIL 5ng/ml R00 exp35	4.72
TRAIL 50ng/ml R00 exp36	4.87

Gene	Correlation
FLCN	0.693
LAMTOR4	0.665
LAMTOR2	0.659
RRAGA	0.595
WDR24	0.591
MIOS	0.564
CCNC	0.527
CASP3	0.519
TBC1D5	0.507
LAMTOR1	0.494
LAMTOR5	0.494
LAMTOR3	0.479
GABARAP	0.468
VPS41	0.454
LSM12	0.448
FBXO11	0.434
TNFRSF10B	0.434
CLK3	0.433
EIF4G1	0.424
PAX5	0.424
FADD	0.421
SPOP	0.42
THOC6	0.414
WDR59	0.413
MED13L	0.406
KHDRBS1	0.406
ZNF217	0.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2859
Expression level (log2 read counts): 5.15

Expression Distribution

positive regulation of B cell apoptotic process
ATPase inhibitor activity
regulation of pro-B cell differentiation
regulation of lymphoid progenitor cell differentiation
immature B cell differentiation
regulation of B cell apoptotic process
positive regulation of lymphocyte apoptotic process
negative regulation of TORC1 signaling
positive regulation of leukocyte apoptotic process
TOR signaling
regulation of TORC1 signaling
negative regulation of TOR signaling
regulation of lymphocyte apoptotic process
negative regulation of mitochondrion organization
regulation of leukocyte apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of cysteine-type endopeptidase activity
regulation of TOR signaling
chaperone binding
guanyl-nucleotide exchange factor activity
positive regulation of peptidyl-serine phosphorylation
B cell differentiation
regulation of peptidyl-serine phosphorylation
cellular response to starvation
B cell activation
regulation of mitochondrion organization
response to starvation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to nutrient levels
lymphocyte differentiation
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
positive regulation of protein complex assembly
negative regulation of peptidase activity
cellular response to extracellular stimulus
leukocyte differentiation
cellular response to external stimulus
negative regulation of proteolysis
negative regulation of organelle organization