GPBP1
Gene Information
- Official Symbol: GPBP1
- Official Name: GC-rich promoter binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 65056
- UniProt: Q86WP2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
- UniProt Summary: Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9558
- Expression level (log2 read counts): 6.7
GPBP1 Expression in NALM6 Cells: 6.7
