IKZF2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FBS-Wisent 0.1 R07 exp426	-3.02
BVD-523 15μM R02 exp67	-2.94
UMK57 1μM R01 exp59	-2.54
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.3
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.24
Atovaquone 15μM R08 exp451	-2.14
Rotenone 2μM R00 exp33	-1.94
Caffeine 2600μM R08 exp463	-1.9
UM131593 0.2μM R03 exp106	-1.89
CoCl2 18μM R07 exp346	-1.83
Olaparib 4μM R08 exp512	1.85
I-BRD9 4μM R07 exp365	1.9
MLN-4924 0.2μM R00 exp21	1.92
Radicicol 0.16μM R05 exp242	1.94
UM0129480 7μM R02 exp85	1.94
Oligomycin-A 2μM R00 exp25	2.01
Tubacin 1.6μM R07 exp416	2.02
Parthenolide 2.5μM R05 exp238	2.11
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.17
Rapamycin 10μM R00 exp30	2.18
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.29
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.59
Thapsigargin 0.005μM R07 exp407	2.96
CR131-b 0.005μM R08 exp474	3.41
GSK626616 14μM R08 exp485	3.46
CB-5083 0.4μM R08 exp468	3.93
VER-155008 3.9μM R06 exp301	4.16
TRAIL 50ng/ml R00 exp36	6.2
TRAIL 5ng/ml R00 exp35	7.29

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

transcription regulatory region DNA binding
DNA-binding transcription factor activity
molecular function
protein homodimerization activity
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process