KREMEN1

Gene Information

Official Symbol: KREMEN1
Official Name: kringle containing transmembrane protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 83999
UniProt: Q96MU8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK343 3μM R03 exp124	-1.75
BI-D1870 2μM R04 exp162	1.7
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.73
DKK1 89ng/ml R08 exp477	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.74
Dimethyloxaloylglycine 11μM R07 exp314	1.75
Nicotine 3000μM R08 exp510	1.78
PNU96415E 10μM R03 exp145	1.79
Alpha-Amanitin 0.5μM R00 exp5	1.84
Chloramphenicol 2μM R00 exp12	1.88
Trametinib 10μM R02 exp83	2.08
Caffeine 2600μM R08 exp463	2.18
NFN1 0.4μM R03 exp99	2.24
Wortmannin 0.5μM R00 exp37	2.6
Rifampicin 10μM R00 exp32	2.65

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2307
Expression level (log2 read counts): 3.48

Expression Distribution

WSC
CUB
Kringle

negative regulation of axon regeneration
negative regulation of neuron projection regeneration
regulation of axon regeneration
regulation of neuron projection regeneration
negative regulation of ossification
negative regulation of response to wounding
negative regulation of neuron projection development
regulation of response to wounding
negative regulation of canonical Wnt signaling pathway
limb development
appendage development
negative regulation of cell projection organization
regulation of ossification
negative regulation of Wnt signaling pathway
negative regulation of neuron differentiation
regulation of canonical Wnt signaling pathway
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
negative regulation of response to external stimulus
neuronal cell body
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of neuron projection development
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of cellular response to stress
regulation of neurogenesis
apoptotic process
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
programmed cell death
cell death
regulation of response to external stimulus