KTI12

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Erlotinib 10μM R05 exp216	-2.07
D-Fructose 10000μM R06 exp279	-1.76
Trientine 500μM R08 exp534	-1.73
MK2206 4μM R08 exp504	1.7
Latrunculin-B 10μM R07 exp374	1.77
Citral 50μM R06 exp274	1.86
Calcium Ionophore 0.4μM R07 exp342	1.9
iCRT14 30μM R08 exp492	1.9
Cannabidiol 20μM R08 exp466	2.09
Chloramphenicol 20μM R00 exp13	2.09
Mubritinib 0.2μM R02 exp65	2.12
Bisphenol A 100μM R06 exp269	2.15
WYE-354 6μM R02 exp90	2.22
UM0129480 7μM R02 exp85	2.25
Artemisinin 50μM R08 exp450	2.27
Mubritinib 0.2μM R01 exp48	2.4
MS023 7μM R03 exp135	2.49
2-Deoxy-D-glucose 800μM R05 exp214	2.62
MS023 2μM R03 exp134	2.79
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.18
Hippuristanol 0.12μM R08 exp488	3.55

Global Fraction of Cell Lines Where Essential: 432/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	15/28
blood	11/28
bone	13/25
breast	14/33
central nervous system	38/56
cervix	1/4
colorectal	11/17
esophagus	7/13
fibroblast	1/1
gastric	7/15
kidney	15/21
liver	14/20
lung	47/75
lymphocyte	5/14
ovary	16/26
pancreas	16/24
peripheral nervous system	9/16
plasma cell	6/15
prostate	1/1
skin	19/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	20/29
uterus	4/5

Expression Distribution

Elongator holoenzyme complex
tRNA wobble uridine modification
tRNA wobble base modification
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
RNA processing
ATP binding
RNA metabolic process
gene expression