NDUFB8

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 48/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	0/28
bone	2/26
breast	6/33
central nervous system	2/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	2/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Expression Distribution

NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial matrix
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
endoplasmic reticulum
mitochondrion
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization