NME6
Gene Information
- Official Symbol: NME6
- Official Name: NME/NM23 nucleoside diphosphate kinase 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 10201
- UniProt: O75414
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Pfam Domains GO Terms
Pfam Domains
| NDK |
GO Terms
| UTP biosynthetic process |
| UTP metabolic process |
| GTP biosynthetic process |
| guanosine-containing compound biosynthetic process |
| CTP biosynthetic process |
| CTP metabolic process |
| pyrimidine ribonucleoside triphosphate biosynthetic process |
| pyrimidine ribonucleoside triphosphate metabolic process |
| pyrimidine nucleoside triphosphate biosynthetic process |
| nucleoside diphosphate kinase activity |
| pyrimidine ribonucleotide biosynthetic process |
| purine ribonucleoside biosynthetic process |
| ribonucleoside biosynthetic process |
| pyrimidine nucleoside triphosphate metabolic process |
| purine nucleoside biosynthetic process |
| pyrimidine ribonucleotide metabolic process |
| GTP metabolic process |
| nucleoside biosynthetic process |
| negative regulation of mitotic nuclear division |
| guanosine-containing compound metabolic process |
| glycosyl compound biosynthetic process |
| purine ribonucleoside triphosphate biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| purine nucleoside triphosphate biosynthetic process |
| negative regulation of nuclear division |
| ribonucleoside triphosphate biosynthetic process |
| pyrimidine-containing compound biosynthetic process |
| nucleoside diphosphate phosphorylation |
| purine ribonucleoside triphosphate metabolic process |
| purine ribonucleoside metabolic process |
| nucleotide phosphorylation |
| pyrimidine nucleotide metabolic process |
| nucleoside triphosphate biosynthetic process |
| purine nucleoside metabolic process |
| ribonucleoside triphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| ribonucleoside metabolic process |
| nucleoside diphosphate metabolic process |
| nucleoside triphosphate metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| pyrimidine-containing compound metabolic process |
| nucleoside metabolic process |
| glycosyl compound metabolic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| regulation of mitotic nuclear division |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| negative regulation of cell growth |
| regulation of nuclear division |
| negative regulation of growth |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| negative regulation of mitotic cell cycle |
| purine ribonucleotide metabolic process |
| negative regulation of cell cycle process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| negative regulation of organelle organization |
| regulation of cell growth |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| negative regulation of cell cycle |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| regulation of mitotic cell cycle |
| regulation of growth |
| negative regulation of cellular component organization |
| regulation of cell cycle process |
| organophosphate metabolic process |
| apoptotic process |
| carbohydrate derivative metabolic process |
| programmed cell death |
| cell death |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| mitochondrion |
| phosphorylation |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 1/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 19064
- Expression level (log2 read counts): 4.81
Expression Distribution
NME6 Expression in NALM6 Cells: 4.81
